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A comparison of group score and data not normally distributed at baseline was undertaken using a Mann-Whitney U test.
A comparison at baseline was undertaken using a Mann–Whitney U test and a chi-squared test for dichotomous variables.
Due to non-normality of the data a comparison at baseline was undertaken using a Mann–Whitney- U-test.
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However, additional confirmatory analyses of the importance of the variables within the multivariable models identified utilising baseline data was undertaken using data from the control arms of this trial.
Comparisons of log cough sensitivity (measured as C5 and cough threshold) between baseline and each visit was undertaken using a generalised linear mixed model (GLMM) with a random intercept term which takes into account the repeated observations on individuals.
To determine the predictive factors of radiographic outcome, univariate analysis of the relationship between baseline values and outcome measures was undertaken using a chi-squared or Fisher's exact test.
Univariate analysis was undertaken using all baseline variables including standard risk predictors of age, diabetes, hypertension, left ventricular ejection fraction and renal function.
Baseline and follow-up comparison of each MICA item was undertaken using Wilcoxon signed rank tests.
Estimation of incremental costs at follow-up was undertaken using GEE regression models controlling for treatment arm, baseline cost and clustering.
Quantitative data analysis was undertaken using SPSS (Version 17.0) utilising ANOVA to assess changes between baseline and follow-up.
Estimation of incremental effectiveness at follow-up was undertaken using GEE regression models, assuming a Gaussian variance function and controlling for treatment arm, baseline EQ5D score and clustering.
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