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Purified DNA from whole-blood samples collected at baseline was analysed using the AmpliChip CYP450 Test at the Roche laboratories (Roche Molecular Systems, Inc., Pleasanton, CA, USA), blind to case control status and all clinical factors.
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Changes from baseline were analysed using a repeated measures model.
Group differences at baseline were analysed using independent Student t tests.
Characteristics of the study population at baseline were analysed using descriptive statistics.
The changes from baseline were analysed using Wilcoxon's signed-rank test.
Two hundred and thirty-three RNA samples, prepared from whole blood, at baseline were analysed using the GeneChip Human Genome U133 Plus 2.0 Array (Affymetrix, Santa Clara, California, USA).
Differences between groups at baseline were analysed using the independent t-test for continuous data (or Mann–Whitney U test for non-normally distributed data).
Progression to DM and recovery of NGT from IFG and/or IGT at baseline were analysed using the Kaplan Meier method.
EQ-VAS changes from baseline were analysed using a mixed model for repeated measures (MMRM) with an unstructured correlation matrix and adjusting for age, duration of prior bisphosphonate treatment and a diagnosis of rheumatoid arthritis at baseline.
Between-group comparisons at baseline were analysed using independent samples t-test or Mann–Whitney U test for continuous variables and χ or Fisher's exact test for categorical variables.
Baseline data was analysed using multiple linear regression.
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CEO of Professional Science Editing for Scientists @ prosciediting.com