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An important result of the present analysis is the way in which a 30% increase of the drug peak concentration in choroid and retina can be obtained from the baseline values, for example to meet a therapeutic threshold.
We carried out multiple linear regression analyses with mixed effects models (allowing for heterogeneity in treatment effect by site) adjusted for the corresponding baseline values (for example, baseline weight for analysis of weight at follow-up), with group allocation and site as fixed effects.
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The percent mean change represents change in a variable relative to baseline value; for example, the percent mean change of fasting glucose was calculated as follows: (glucoseafter treatment – glucosebefore treatment) divided by glucosebefore treatment.
Baseline values for each parameter are presented.
MIC values were different for patients with low or high baseline values for all 3 instruments.
Despite sustained pulmonary hypertension, pulmonary capillary pressure remained at baseline values for the duration of the study.
There were no statistically significant differences between these baseline values for brain reward thresholds and response latencies indicating that the repeated treatment procedure did not alter baseline performance (p>0.05).
These values were used as baseline values for each MPDS.
Another subtyping method may define the baseline value differently (for example, it may be the mean); regardless, our approach, as presented below, would still apply.
These were calculated using the mean of respective differences from the baseline value for each group for two consecutive time points when testing took place, for example, Days 1 and 7, multiplied with the number of days in this interval.
baseline value for SOC [14].
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