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On all postoperative days tested, mechanical withdrawal thresholds of the uninjured paw (contralateral to paw incision) did not significantly differ from baseline values (data not shown).
Frequencies of CD4+ T cells expressing at least IFN-γ, TNF-α or CD40L were not significantly higher than baseline values (data not shown).
Myo-Inositol (MI) levels show an increase at 2 and 4 weeks after inoculation and then normalization to baseline values (data not shown).
The fall in ACPA levels was greatest in patients with higher baseline values (data not shown).
After the 14-day administration of LWDHW, the mean values of parameters used to assess safety (i.e., systolic and diastolic blood pressure, FSH level, complete blood count, and kidney and liver function) did not differ statistically or clinically from the baseline values (data not shown).
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ROTEM EXTEM CT, CFT, MCF and alpha did not differ at baseline and after 24 hours, nor did G values (data not shown).
Twenty-four subjects had a baseline CRP level below 2 mg/l; 6 individuals had levels greater or equal to this value (data not shown).
We looked at the prognostic value of baseline albumin (data not shown), and we did not find any impact on survival.
Demographic data and baseline values were comparable (not statistically different) between the NS2359 and placebo groups.
Missing efficacy data were imputed using the last observation carried forward (LOCF) method; baseline values were not carried forward.
Based on a rise in mean ET-1 values or percentage change from baseline (data not shown), there was no evidence of a dose-related response across the 2.5 240 mg (twice the maximum well-tolerated dose) dose range tested.
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CEO of Professional Science Editing for Scientists @ prosciediting.com