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To evaluate changes in average MBR, the rate of change in average MBR vs. initial baseline value was utilized, as previously described [ 11, 12].
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For the primary efficacy endpoint, Least Square Means from a repeated measure ANCOVA model with effects for study center, treatment, visit, visit by treatment interaction, and baseline subscale value were utilized to assess difference between treatment groups.
These values are utilized in the Pfaffl analysis.
Baseline value was 100%.
In the intervention group, baseline data was utilized in two patients.
As a limitation of our analyses, only frailty status at baseline was utilized.
A baseline last observation carried forward imputation method was utilized to impute missing data replacing the missing value with the baseline value if the responder rate was missing at week 32 for any reason.
An E-value cutoff of 10-5 was utilized.
The baseline values were used for calculating the baseline-corrected measures during the task (see below).
Baseline values were included in the regression model.
Baseline values were comparable between the treatment groups.
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