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Rapid elevation of CAR transgene copy numbers (>2.5-fold of the baseline value) was observed in 9/11 patients, meanwhile, 9/11 patients' serum CAR transgene copy numbers were still above 2-fold of the baseline level.
Rapid elevation of CAR transgene copy numbers (>2.5-fold of the baseline value) was observed in 9/11 patients following the infusion of CART-HER2 cells, indicating robust expansion of CART cells in vivo (Fig. 4).
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Additional infusions of 5 ml/kg were provided at 30, 60, 120, and 180 min if hypotension (MAP < 60 mmHg) or tachycardia (HR > baseline value)were observed.
A decrease in hs-CRP over baseline values was observed in 79% of patients (42 of 53) treated with pravastatin.
After an initial improvement in estimated maximal oxygen uptake in both groups, which was greatest in the intervention group (VO2max 0.3 l/min; p = 0.006, 4.0 ml/kg/min; p<0.001), a gradual decline toward baseline values was observed during follow-up (Figure 3).
Linear interpolation was used to determine the provocative concentration of MCh aerosol at which a 200% increase (PC200) over baseline values was observed for Penh values.
Even when a significant difference was reported [ 9], a marked overlap of individual baseline values was observed, so that no threshold value could help to discriminate responder and nonresponder patients.
On the other hand, the GF of EAE mice at 20 and 30 dpi was significantly lower compared with HC (both P ≤ 0.05), though a return toward baseline values was observed between 60 and 90 dpi (Table 1).
These improvements were sustained at the 26 weeks time point for all three groups and at 52 weeks for the supervised NW group whereas a return towards baseline values was observed at 52 weeks for the unsupervised NW and the advice to remain active group.
Second, the typical quadratic pattern of stressor-elicited fluctuations in this measure was similar in both Sprague Dawley and Long Evans rats, with consistently elevated levels for the first hour following exposure to the acute stressor; near baseline values were observed at 2 h.
No differences in baseline values were observed between the cohorts of mice tested (0 weeks; Figure 1C).
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