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Body core temperature dropped from 36.0 ± 0.7°C at baseline to a minimum of 35.7 ± 0.7°C, and increased significantly (p < 0.001) thereafter to 37.1 ± 0.7°C until the end of surgery.
We did not observe any significant changes in heart rate or blood pressure indicating beginning hypovolaemia.Body core temperature dropped slightly from 36.0 ± 0.7°C at baseline to a minimum of 35.7 ± 0.7°C (range 34.0.. 37.1°C), and increased significantly (p < 0.001) thereafter to 37.1 ± 0.7°C at the end of surgery (see Figure 1).
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Data analysis when at least two baseline measurements are available may use minimum baseline to minimum post baseline and maximum baseline to maximum post baseline changes to account for within subject variation [ 13].
The a-wave amplitude was measured from the prestimulus baseline to the minimum value of the first negative deflection.
To minimize this, it would seem appropriate to design trials such that the spread of relevant baseline characteristics is kept to a minimum or at least controlled for so that there is sufficient power in the study to allow multivariate or predetermined subgroup analyses.
Information on HbA1c (A1C), medication use and co-morbid conditions was extracted from the medical record up to 6 months prior to the addition of SU or TZD to MF (baseline), and a minimum of one year after the initiation of either SU or TZD.
We analyzed the curve integrals expressed as arbitrary units (aU) of hypoxic (INThypo) and hyperoxic (INThyper) ptiO2 responses, and assessed the portions from start at baseline to minimum as descent integral (descINThypo) and to maximum as ascent integral (ascINThyper), respectively.
Investigators were asked to gradually decrease the dose of the SSRI or SNRI during the week prior to baseline to reach the minimum therapeutic dose.
To be considered acceptable, in addition to control group to establish endpoint baseline, a minimum of 3 dose levels were required.
During the infusion, fluid and additional vasopressor support (beyond baseline needs) to maintain a minimum PWP of 15 mmHg and a mean arterial pressure (MAP) of 65 mmHg was mandated; however, no subject required such support.
We kept within-group variation to a minimum to set up the baseline performance of our method.
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