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It is essential to determine their baseline susceptibility to HIV entry inhibitors before these drugs are used in China.
Under each hypothesized model, we also estimated the susceptibility allele frequency, transmission probabilities for the susceptibility allele, baseline susceptibility and estimates of familial association.
The present study aims to test the baseline susceptibility of the predominant HIV-1 subtypes circulating in China to HIV entry inhibitors and characterize the genotype polymorphisms in these subtypes.
In other words, the baseline drug susceptibility of "wild-type" viruses varied among different patient-derived HIV strains, and this range of baseline susceptibility should be kept in mind when considering the susceptibility of resistant viruses.
Our results suggest that there are significant differences in baseline susceptibility to HIV entry inhibitors among the predominant HIV-1 subtypes in China and the differences may partly result from the naturally occurring polymorphisms in these subtypes.
The baseline susceptibility of 14 representative HIV-1 isolates (5 CRF07_BC, 4 CRF01_and and 5 B'), most of which were R5 viruses, obtained from drug-naïve patients to HIV entry inhibitors, including two fusion inhibitors (enfuvirtide and C34), two CCR5 antagonists (maraviroc and TAK779) and one CXCR4 antagonist (AMD3100), were determined by virus inhibition assay.
Similar(49)
Hence, in the following computation of two baseline landslide susceptibility maps, an alternative pair of landslide susceptibility maps is computed by using revised weights obtained from GSA (see Table 3 columns c e).
To determine the baseline antibiotic susceptibility patterns of conjunctival and nasopharyngeal flora isolated from patients undergoing intravitreal (IVT) injections for choroidal neovascularization (CNV).
Of the 194 patients with disease caused by Mycobacterium tuberculosis we excluded those with no baseline drug susceptibility testing (DST) results available (6 cases), and those whose baseline DST results did not meet the definition of MDR-TB (confirmed susceptibility to either isoniazid and rifampicin) (13 cases).
Two p53-mutated tumor cell lines (CAMA-1 and HT29) showed insignificant baseline adenoviral susceptibility.
Certainly DRV/r appeared to spare future PI use more so than LPV/r in the TITAN trial, as seen in Figure 2. Baseline tipranavir susceptibility was maintained in a number of studies, despite DRV virological failure, suggesting it will remain an option, even in the heavily treatment-experienced population.
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