The outcomes of the patients are probably more dependent on the underlying cause, rather than on the baseline severity of the hypoxemia itself.
Explicit incorporation of costs into such planning is considered in this article in the situation where effects of an intervention or treatment may depend on (interact with) baseline severity of the targeted symptom or disease.
This indicates that the effects of baseline severity on outcome did not differ for the different conditions.
54 A corresponding analysis examining the influence of baseline severity on outcomes in SITS and VISTA data is under way.
Premorbid functional status, however, is difficult to establish reliably in patients with stroke, and the strong influence of baseline severity on outcome, for which we did adjust, is known.
4 A recent review of published data found that treatment duration with one BoNT/A product in females ranged from 3 to 5 months, using a conservative definition of relapse rate as a return to baseline severity on two consecutive visits approximately 30 days apart.
14 The outcomes, and therefore the HRs for death, depend not only on the baseline severity, but also on the treatment and patient conditions, including complications.
These factors are probably surrogate markers of clinical severity and its association with mortality is in line with the results of other studies that pointed out the influence of factors related to baseline clinical severity on the outcome of A. baumannii infections [ 13, 14, 17, 20, 21].
In the group of all 598 depressed patients, patients with a baseline severity ≥ 14 on the HAM-D-17 had 7.23 points (95% CI 5.31-9.14 p<0.001) more improvement on the MADRS than patients meeting the exclusion criterion of 'not meeting minimum severity threshold'.
The primary analysis used regression methods to estimate group differences in outcomes at six months after adjustment for the intended stratification criteria (site, diagnostic group, and baseline severity of communication impairment on the Therapy Outcome Measure).
