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The baseline risk of malignancy has not been established for patients with IED, with or without systemic manifestations.
Other studies did not account for this baseline risk of malignancy in RA, which may inflate their malignancy incidence findings [57].
Isomaki et al. suggested that the baseline risk of malignancy in patients with RA might be due to chronic activation of the immune system, leading to an increased incidence of lymphoproliferative disorders.
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With more biologic treatment options available and initiation of biologic treatments occurring earlier, it is important to understand the baseline risk of malignancies in patients with RA.
They tend to be sicker patients facing a higher baseline risk of cardiovascular disease, Glaxo said.
It is thought that tumours <5 cm are usually at low risk of malignancy and tumours >5 cm are malignant.
Although of limited value, patients usually have a baseline thyroid function test, as a hyperfunctioning nodule with suppressed TSH is associated with a low risk of malignancy [ 23].
Also, the risk of malignancy for the affected individuals is high.
Surgical removal of mucinous cystic neoplasms (MCNs) is usually recommended because of the risk of malignancy.
Conclusions: Postmenopausal women with endometrial polyps are at increased risk of malignancy in the polyp.
Some meta-analyses have evaluated the risk of malignancy.
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