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Baseline responses were obtained every 10 sec, and 3 6 responses were averaged to obtain a data point.
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An average normalized baseline response was obtained from days −1 to −4 (prior to the onset of neurological disability).
The baseline (with no TMS) MMN responses were obtained using 2 methods.
Peak FRET responses were obtained by subtraction of the baseline from the averaged peak response.
The two highest gamma responses were obtained with the foreign and native language perception tasks with the former showing the strongest deviation from baseline.
20 responses were obtained for each condition.
Forty-two responses were obtained (86%).
Once a stable baseline of responses was obtained for at least 20 min, we either (1) recorded I/O in the presence of capsaicin and then continued single pulse stimulation for 15 min, or (2) in drug-free conditions, directly delivered high-frequency stimulation (HFS) as two trains at 100 Hz (duration: 1s, 30 s apart).
No objective response was obtained.
Enrollment and baseline surveys were obtained on 1554 participants (53% response rate; range: 34% to 92% participation rate across the different housing sites).
The baseline measures were obtained before randomisation.
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