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Only patients with documented normal baseline renal function were included.
Indeed, two recent clinical experiences assessing the safety of intravenous voriconazole in patients with compromised renal function showed that the route of administration and baseline renal function were not predictors of worsening renal dysfunction [ 83, 84].
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Impaired baseline renal function is a common condition in patients with SRMs, especially in the case of advanced age or other underlying comorbidities like diabetes.
Baseline renal function was further categorized into CrCl <50 ml/min and ≥50 ml/min.
Baseline renal function was categorized according to CrCl as follows: normal (CrCl ≥90 ml/min), mild (CrCl 60 89 ml/min), moderate (CrCl 30 59 ml/min) and severe renal impairment (CrCl <30 ml/min).
Baseline renal function was within normal range.
Baseline renal function was determined in 1,239 women.
aWhere baseline renal function was not available, patients are assumed to have normal baseline renal function.
Baseline renal function was defined as the lowest known SCr value during the preceding 3 months.
In conclusion, baseline renal function is the best clinical predictor of a response to therapy in patients with IRPGN.
Challenging the issue of baseline renal function is thus crucial for validating the potential usefulness of biomarkers in clinical practice.
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CEO of Professional Science Editing for Scientists @ prosciediting.com