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At 6 weeks of age mice lacking PPR signaling in T cells have a normal bone phenotype, and normal serum calcium, phosphate and PTH levels, indicating that PPR signaling in T cells does not play a major role in bone modeling and baseline remodeling.
This enabled us to compare the effects on regenerating bone with those on bone undergoing normal baseline remodeling.
Bisphosphonates are retained in bone in the remodeling resorption cavity and the amount of bisphosphonate retained in probably a function of the baseline remodeling space, the chronic rate of bone turnover and the GFR.
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Baseline measurement for bone remodeling studies with DXA can therefore be done at any time in this interval.
Five trials [ 7, 8, 11, 12, 15] assessed the effect of CRT on LV remodeling by comparing baseline and endpoint echocardiographic parameters.
In multivariate analysis, none of the 3 biomarkers at baseline was independently predictive of LV remodeling.
These findings are consistent with our observation that LCR hearts have increased geometric dimensions and SV at baseline which may reflect a compensatory remodeling response to this increased β-MHC in the heart.
Bone remodeling around the cup between baseline (postoperatively) and 2 years was similar in the 2 groups.
At baseline, we found significant univariate relations between LV remodeling and the 3 biomarkers.
In this latter study, of the baseline variables only ISF was able to predict reverse remodeling [ 79].
To assess the sensitivity of our propensity matched models to potential confounding secondary to imbalance of baseline MRI metrics, we remodeled treatment arm as a predictor of first on-treatment relapse, switch therapy discontinuation and 3-month confirmed disability progression incorporating baseline cerebral MRI metrics, where available, as adjusting covariates in the Cox marginal model.
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