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As shown in Figure 5D, siSIRT3 decreased the baseline protein level of SOD2 and reduced the induction of SOD2 by PGC-1α (Fig. 5D).
On the other hand, similar to the transcriptional results seen with Compound A, the knockdown of p65 did not alter the baseline protein expression of XIAP, Survivin, or Bcl-xL (Figure 2B).
Data were analyzed with GraphPad Prism statistical software using two-tailed t-test (for comparison of baseline protein levels) or two-way ANOVA with ad hoc Bonferroni post-test (for comparison of drug treatment effects between the two cell types).
Baseline protein C classes were initially included.
Q2: Do baseline protein kinetics change during early ICU treatment?
Rapamycin inhibited the phosphorylation of p70S6K, but had no significant effect on baseline protein synthesis.
Baseline protein levels were initially compared between patients with active TB and control subjects.
Both sexes returned to baseline protein levels and morphology following recovery.
Question 2: Do baseline protein kinetics change during early ICU treatment?
Furthermore, early changes in protein C levels, in combination with baseline protein C levels, predict outcome.
Baseline protein C measurements were obtained for 1574 patients (799 receiving DrotAA and 775 receiving placebo).
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