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Study participants provided signed informed consent before baseline procedures were performed.
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Spectral phasing and baseline correction procedures were performed automatically using TopSpin (v 2.1, Bruker BioSpin, Rheinstetten, Germany).
All baseline imaging procedures were performed within 4 weeks before the study entry.
All baseline measurements and sampling procedures were performed before the instillation of bacteria at 0 h.
After the first infusion (Cycle 1), the investigative site completes a subject referral form referring the patient to home care, confirming that the patient had consented to the referral (informed consent occurred during the baseline period before any study procedures were performed), and containing information required by the home care team for the appropriate scheduling of the home visits.
The day of implant surgery (day 0) was the baseline time point; patient consent and screening procedures were performed between 8 weeks and 1 day before day 0. Implant surgery and placement were performed according to the manufacturer's recommended guidelines.
In total, estimation procedures were performed in 2.6% (14 simple records) of baseline values.
Sometimes procedures were performed without light or anesthesia.
All procedures were performed in a quiet room with a constant temperature of 25°C, and the subjects rested in the supine position for 30 min before baseline measurements.
Synthetic procedures were performed manually.
The procedures described under "General procedures" were performed.
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