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But, other times, they are much more provisionally held, like the baseline mutation rate of the genome.
Neel collected blood samples to study humans in their natural condition (his description) to see what the normal baseline mutation rate was for humans and to see how human behavior affected genetic variation.
This result differs from the baseline mutation spectrum in C. elegans MA lines in Denver et al. [ 19].
Because of the previously described study limitations and because currently there are no definitive international baseline mutation specific estimates of penetrance for risk of breast cancer among BRCA1/2 mutation carriers, however, this estimate should be interpreted with caution.
Note that excluding monomorphic STS effectively increases the baseline mutation rate by ~1.6 (48/30), but this value is within error ranges of mutation range estimates, and does not affect scaling of parameters across groups.
Statistical analysis confirmed that the elevated mutation rates in these three MSS CRC cell lines are significantly different from the baseline mutation rates in the nonmutator CRC cell lines (P=0.0013, unpaired t-test).
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None of them had had baseline mutations.
Two patients had detectable baseline mutations.
The neoadjuvant approach is distinct from efforts that simply correlate baseline mutations with relapse-free survival, because relapse data in adjuvant endocrine therapy combine the effect of a mutation/amplification on both prognosis and prediction.
As a whole, patients with ≥1 mutation had response rates (CHR, 83%; MCyR, 58%) that were similar to those observed for patients without baseline mutations (CHR, 90%; MCyR, 59%).
To counter this, and come up with an effective treatment strategy, it has become vital to determine baseline mutations associated with drug resistance among the circulating strains of HIV-1in Kenya.
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