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Overall, the majority of subjects were female (70%) and Caucasian (86%), with a mean age of 51.1 years, baseline mean weight of 103.1 kg and mean BMI of 36.6 kg/m [27].
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Compared with the baseline, mean weight loss at treatment completion of 25 fractions was 7 kg, which corresponded to a percentage of 13.6% (range, 3.9 25.5%).
At baseline, the mean weight of the 302 patients was 68.6 ± 11.3 kg (median: 67 kg, IQR range 60 75 kg).
At the end of the 12 weeks of exercise programme, compared with the baseline, the mean weight of both the male and female participants also changed significantly (P < 0.05) from 83.9 ± 11.2 kg to 71.6 ± 8.0 kg and from 91.5 ± 9 kg to 84.6 ± 4.4 kg, respectively.
37 After 26 weeks of therapy, mean weight changed from baseline by −2.0 kg in the EQW group compared with −0.8 kg in the sitagliptin group (P<0.001).
The mean baseline weight for responders was 96.4 kg compared with a mean weight of 101.5 kg for non-responders.
In our pilot study, participants had a mean weight of 98.1 kg (SD 17.3 kg) at baseline.
The weight-loss group (n = 314; 12.2%) began at a mean weight of 109.3 kg and lost weight until about 18 months, reaching a mean of 98.6 kg (9.8% loss), followed by a regain to approximately baseline weight.
The weight-gain group (n = 300; 11.7%) began at a mean weight of 107.8 kg and gained weight until about 18 months, reaching a mean of 114.7 kg (6.4% gain; P < 0.001), followed by a weight loss; ending mean weight was near baseline.
In the self-directed group mean weight loss reached 5% only among those with a baseline BMI of <35.
At baseline, mean HbA1c and mean weight were 8.1% and 86.5 kg, respectively.
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