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The degree of BHR at 9 years was significantly related to current clinical status, baseline lung function, and parental atopy.
Black subjects were slightly younger, had better baseline lung function, and were less likely to suffer from obstructive lung disease; in addition, they were more likely to be female and never smokers (p<0.01 for all).
In conclusion, these data demonstrate that IL-13 neutralisation reduces airway inflammation, normalises baseline lung function and reduces AHR to inhaled spasmogen in a mouse model of asthma driven by a clinically relevant aeroallergen administered by the inhaled route only, and without the use of experimental adjuvants.
Higher year 7 fibrinogen was associated with greater loss of forced vital capacity (FVC) between years 5 and 20 (439 mL in quartile 4 vs. 398 mL in quartile 1, P<0.001) and forced expiratory volume in 1 second (FEV1) (487 mL in quartile 4 vs. 446 mL in quartile 1, P<0.001) independent of cigarette smoking, body habitus, baseline lung function and demographic factors.
Furthermore, after additional adjustment for baseline lung function and report of cough or phlegm, the trend was even stronger.
The two groups were well matched in terms of demographic characteristics, duration of diabetes, baseline lung function, and glycemic control.
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After measurement of baseline lung functions and hemodynamics, the experiment was terminated.
We observed a highly comparable distribution of sex, age, baseline body mass index, weight change during follow-up, baseline lung function level, and average PM10 exposure at baseline and during follow-up, except for a small difference in proportion in smokers and smoking intensity between the two samples (Table 1).
Table 11 compares baseline lung function differences and across shift changes in lung function between women and men in the 3 industry groups.
Physical examinations, baseline lung function tests and methacholine challenge tests were scheduled at ages 16 months and 5, 7 and 9 years.
Age, baseline lung function, AR, and change in BMI were included in the final regression analyses.
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