Subsequent post hoc testing revealed a significant increase in ethanol consumption during mania-induction compared with the baseline interval in the LHK (t = 4.707, P < 0.01) and in the NAC group (t = 3.071, P < 0.05) but not in the ILC group (t = 2.79, P > 0.05).
An interaction between time and group (F6,32 = 2.97, P = 0.02) and subsequent post hoc testing revealed a significant increase in activity counts during mania-induction compared with the baseline interval in the LHK (t = 4.73, P < 0.001), NAC (t = 2.77, P < 0.05), and ILC (t = 2.66, P < 0.05) but not in the LHT-sham (t = 1.17, P > 0.05, Figure 4B).
Total rest interval during dark phase (D) shows no significant decrease in total duration of rest during mania induction compared with the baseline interval in the LHK (P > 0.05), NAC (P > 0.05), or LHT-sham (P > 0.05) but and a significant increase in the ILC (P < 0.05) with an interaction (P = 0.0005) by two-way ANOVA; *P < 0.05 by post hoc test; n = 8 to 12 per group.
An interaction between time and group (F6,32 = 2.97, P = 0.0005) and subsequent post hoc testing revealed no significant decrease in total duration of rest during mania-induction compared with the baseline interval in the LHK (t = 1.04, P > 0.05), NAC (t = 0.585, P > 0.05), or LHT-sham (t = 1.33, P > 0.05) and a significant increase in the ILC (t = 2.78, P < 0.05, Figure 4D).
Total rest interval during light phase (C) shows a significant decrease with interaction (P = 0.009) during mania induction compared with the baseline interval in all groups, the LHK (*P < 0.001), NAC (*P < 0.001), ILC (*P < 0.01), and in the LHT-sham (*P < 0.05).
An interaction between time and group (F6,32 = 2.97, P = 0.009) and subsequent post hoc testing revealed a significant decrease in total duration of rest during mania-induction compared with the baseline interval in all groups, the LHK (t = 6.764, P < 0.001), NAC (t = 5.626, P < 0.001), ILC (t = 3.323, P < 0.01), and in the LHT-sham (t = 3.173, P < 0.05, Figure 4C).
When analyzing the induced brain activity, the outcome can be a reduction or an enhancement of the spectral power relative to the baseline interval in defined time-frequency bins.
In the second follow-up interval, the median ACR value in the early GFR loss group was significantly higher than in the stable renal function group, as noted in the baseline interval, and in neither group did the median values increase by the end of follow-up.
The mean number of standard drinks consumed daily in the baseline interval (i.e., the interval between screening and the beginning of treatment) was 8.8 (± 1.6).
During the baseline interval, AER was identical in decliners and nondecliners in the NA group, but MA developed in three times as many decliners (54%) as nondecliners (17%) during the 4 years of follow-up.
Risk-adjusted CUSUM plots showed an increase in the numbers of lives saved per 100 patients treated in all hospitals, from 6·47 in the baseline interval (299 patients included) to 12·44 after implementation (427 patients included) (P < 0·001).
