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The primary efficacy variable was the change from baseline in the average diurnal IOP at month 3.
After 4 weeks, both treatments showed a significant (p < 0.001) reduction from baseline in the average 24-h glucose.
The end point of 24-hour efficacy was assessed by the mean change from baseline in the average AM instantaneous total symptom score (TSS) over the treatment period.
Weekly means of change from baseline in the average pain severity ratings from patient diaries were analyzed using a likelihood-based, mixed-effects model repeated measures (MMRM) approach that used all available observations.
Although complete AK lesion clearance was not seen in this study, a significant reduction in the mean change from baseline in the average lesion area was observed at weeks 3 (P=0.002), 6 (P<0.001), and 12 (P<0.001) in the CPA group, but only at weeks 6 and 12 in the placebo group (P=0.005 and P=0.002, respectively).
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The mean change from baseline in the monthly average number of migraine days were assessed using a mixed-effect model for repeated measures.
In baseline, the average expenditure per prescription of the 274 doctors was 42.82 RMB yuan (USD 6.97), the percentage of prescriptions requiring antibiotics was 63.00%, and the percentage of prescriptions requiring injections was 70.79%, all higher than the average of Hubei Province and the standard recommended by WHO.
While the most important cue nominated at 3 months is not necessarily the same as that nominated at baseline, the change in the average level of the most important cue may reflect a significant treatment effect.
Improvements compared to baseline were noted in the average ICRS functional score, visual analog scale (VAS) pain score, and the patients' rating of the function in the affected knee compared to the contra-lateral knee.
In the baseline condition, the average number of branches was 9.8 ± 0.9 in the control group.
In the baseline conditions, the average (mean ± SEM of samples 4. 6).
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