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The study population consisted of 15,134 subjects without chronic MSCs and valid exposure data on smoking at baseline (HUNT 2).
Adjusted for maternal age at baseline (HUNT 2 participation).
Adjusted for paternal age at baseline (HUNT 2 participation).
Additionally adjusted for maternal height, maternal age at birth, duration between baseline (HUNT 2 participation) and delivery, maternal education, parity, smoking, receiving social security benefits or not, pre-pregnancy maternal hypertension, diabetes mellitus, kidney and heart disease, BMI, systolic and diastolic blood pressure, blood concentration of glucose and lipids.
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The remaining 6,880 had insomnia-symptoms at baseline in HUNT 2. The flow chart of participants in HUNT 2 and HUNT 3 is shown in Figure 1. Figure 1 The flow of participants in HUNT 2 and HUNT 3. The study was approved by the Regional Committee for Ethics in Medical Research.
Demographic and clinical characteristics at baseline in HUNT 2 are given in Table 1 separated by frequency of RA in HUNT 3. Individuals who visited church/prayer house 1 3 times/month or more than 3 times/month were older than those with less frequent visits.
Individuals who suffered from headache at baseline in HUNT 2 were more likely to be fRA at follow-up 11 years later than headache-free (OR = 1.13, 95% CI 1.05-1.22).
Additional adjustments for obstetric and socioeconomic measures (maternal age at delivery, time between baseline at HUNT 2 and delivery, parity, offspring sex, maternal smoking, educational status, and receiving social benefits or not) did not influence the effect estimates.
A prospective cohort method was applied in the present paper using questionnaire data from the 2 399 students who participated both in Young-HUNT 1 (baseline) and in Young-HUNT 2 (follow-up).
Both at the HUNT 2 (baseline) and at the HUNT 3 (follow-up) the participants were asked whether they were dependent on help to perform activities of daily living (ADLs) and instrumental activities of daily living (IADLs).
Additionally adjusted for maternal age at birth, duration between baseline (maternal participation in HUNT 2) and delivery, maternal education, parity, smoking, receiving social security benefits, pre-pregnancy maternal hypertension, diabetes mellitus, kidney and heart disease, BMI, systolic and diastolic blood pressure, blood concentration of glucose and lipids.
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