It is interesting that our baseline gene expression data showed major difference in gene expression between sensitive and resistant cell lines.
To evaluate the effect of combing two cell types on the gene expression of relevant genes, the change for each culture group relative to its own expression on day 1 (as different culture groups showed significant differences in baseline gene expression on day 1) was statistically assessed using the parameter ΔΔ Ct.
An additional advantage is that we are directly measuring differences in baseline gene expression, without regard for either the polymorphism that caused them or their hereditary origin.
By selecting fibroblasts derived from the labioscrotal swellings in normal and CAIS individuals, we were able to largely exclude androgen- independent mechanisms as a cause of systematic differences of baseline gene expression.
We generated expression profiles of several different control KCs and KCs harboring episomal copies of entire HPV16 or 18 genomes [28], [29] on microarrays representing 24,500 well-annotated transcripts to study differences in the baseline gene expression by the presence of HPV.
We determined that while there were baseline gender specific gene expression differences in the kidney, different genes were differentially expressed in diseased kidneys.
Sources of variation in baseline gene expression levels from toxicogenomics study control animals across multiple laboratories.
This study investigates baseline gene expression signatures in patients who respond to PD1 therapy and establishes a T cell-inflamed gene expression signature as a predictive biomarker.
Geeleher, P., Cox, N. J. & Huang, R. S. Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines.
Although the expression of these genes was relatively unaffected by a single bout of resistance exercise in older men, acute exercise altered gene expression in younger men such that post-exercise gene expression in younger men was similar to baseline gene expression in older men.
