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Differentially expressed (DE) putative virulence factors of the orange complex when comparing the baseline expression profiles of active and inactive sites.
Differentially expressed (DE) putative virulence factors of the red complex when comparing the baseline expression profiles of active and inactive sites.
We compared the baseline expression profiles of these patients to those of 18 age- and sex-matched healthy controls.
Pathway and Gene ontology analysis applied to baseline expression profiles of peripheral blood cells from MetS and T2DM patients revealed metabolic changes, highly similar to a reoviral infection gene signature in T2DM patients.
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However, it has to be noted that river sediments are highly complex and vary in abiotic and biotic properties, thus significantly contributing to the modulation of baseline expression profiles.
This might be a gentle stimulation of the spared gene allele, still under the control of the regulatory elements which shape its baseline expression profile and mediate subtle modulation of its levels linked to neuronal physiology.
We used only the baseline expression profile and the expression profiles treated with each individual drug/compound, with a limited number of conditions and replicates to predict synergistic effects of drug/compound combinations.
Alternatively, these compensatory mutations maybe also restore the baseline gene expression profile of cells.
The first stage represents the baseline and denotes the gene expression profiles of patients at diagnosis.
When we compared the expression profiles of baseline and follow-up samples from non-progressing sites (that is, sites that did not change based on CALs) we did not identify any gene as differentially expressed, indicating that clinically stable sites did not have significant changes in gene expression during the period we studied those sites.
In order to identify activities that could be related to the initial steps of disease progression we compared community-wide expression profiles of samples at baseline from sites that did not progress vs. sites that did.
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