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The lower concentration of unchanged radioligand in plasma in baseline experiments may be ascribed to a depletion through binding to abundant TSPO receptors in peripheral organs that does not occur under TSPO blocking conditions.
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Immuno-precipitation experiments may be useful.
Sometimes thought-experiments may be enough.
Sure, the NJ experiment may be just that.
Furthermore, as the sample size of most animal experiments is relatively small, important baseline differences may be present.
Reported baseline characteristics may be incomplete.
Comparison with baseline scans may be useful.
Your baseline may be too high.
Baseline experiments have been conducted in the temperature range 15 200 °C.
Using the pre-development baseline, a "developed-excess" measure may be computed for changes due to anthropogenic development.
Indeed, the experiment would suggest they may be polar opposites.
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