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The baseline dose was calculated as the mean dispensed WHO defined daily doses per day during the 91 day period before baseline.
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The baseline insulin dose was calculated as the average number of units used per day for 3 days prior to the first visit.
As a linear increase in endoxifen plasma concentration was assumed with increasing tamoxifen doses, the individual tamoxifen escalation dose was calculated by the formula: 20 mg × (average endoxifen serum concentration in EMs/patient's baseline endoxifen serum concentration).
The radiation dose was calculated for random samples.
The injected dose was calculated as described above.
The effective dose was calculated as 8.8 μSv/MBq.
The effective dose was calculated using the International Commission on Radiological Protection 103 recommendations.
Mean dose was calculated by dividing the cumulated dose by the cumulated duration of catecholamine administration.
The ratio of the actual dose taken to the prescribed dose was calculated and used to calculate relative dose intensity.
Two indicators of treatment dose were calculated.
For patients randomized to GXR, expected body weight-based dosing was calculated on the basis of patients' assigned GXR dosage and baseline body weight.
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