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The mean difference between groups at eight months, adjusted for baseline differences, was not statistically significant (0.5 prescriptions (95% CI -0.04 to 1.0; p = 0.07).
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Tests of baseline differences are not necessarily wrong, just illogical.
Statistical significance testing of baseline differences is not recommended in trials generally and is inappropriate with small numbers when large differences between groups are likely to be not statistically significant because of limited power.
Most of these baseline differences were not statistically significant except for the number of CD8-positive cells, CD163-positive cells and MMP3 expression, which were significantly higher in the adalimumab group.
Unfortunately the baseline difference was not elucidated until the end of the trial and it was thus judged to be of little meaning to ask participants with little intake of energy from carbohydrates in the low-carbohydrate group at baseline whether this was a consequence of the randomisation, which had occurred more than 2 years earlier.
At 24 months hysterectomy patients improved on all dimensions compared to baseline, but differences were not statistically significant.
Sitagliptin also increased sRAGE concentration relative to baseline, although the differences were not statistically significant.
Carbohydrate intake was higher in the HF, HG, and HS interventions compared with baseline, but the differences were not significant.
However, the results should be viewed with caution since the subgroup was not randomized, and in those patients with moderate to severe baseline ischemia the differences were not significantly significant after Cox risk adjustment was performed.
Patients had significantly less dyspnoea and more sleep disturbances in the XELOX group than in the FOLFOX-6 group at baseline, although these differences were not clinically relevant as the differences in scores were less than the MID of 10 points.
The use of proton pump inhibitor was slightly higher among patients without active inflammation at baseline, but the difference was not statistically significant between cohort with and without baseline active inflammation (P=0.09).
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CEO of Professional Science Editing for Scientists @ prosciediting.com