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However, it is not clear whether baseline differences in bone and body composition between transsexual persons and controls before cross-sex hormonal therapy play a role.
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There were also no internal baseline differences in metaphyseal or diaphyseal bone morphology between left and right hindlimbs of age matched control mice and, therefore, the average of the two limbs for any given index was used for further analysis.
Importantly, the cartilage changes are largely dependent on baseline differences in cartilage volume, tibial bone area, BMI and knee pain, suggesting that these factors might have a role in their initiation.
Marked baseline differences in plus-maze performance were present in the first experiment.
However, the magnitudes of baseline differences in anthropometric measures (z scores) persisted throughout the study.
At 6 and 12 weeks, bone marker concentrations were not different from baseline, and no significant differences in bone marker concentrations were observed between treatment groups at either 6 or 12 weeks.
There were no significant differences in bone turnover markers (OC, bALP, DKK-1, sRANKL, OPG, and sRANKL/OPG ratio) at baseline according to gender and age except for OPG.
No differences in bone density were observed among treatments.
These compositional and architectural alterations in OA bone reflect differences in bone metabolism and remodelling compared to normal bone physiology.
The study had limited power to detect small differences in bone density and bone turnover markers.
There were no qualitative differences in bone healing between groups.
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