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Although presentation of the happy and sad conditions was counterbalanced and two minutes separated these conditions, the possibility exists that the resulting arousal from one condition was not permitted enough time to return to baseline before administration of the following condition.
At baseline, before administration of endotoxin or placebo (180 minutes after completing the surgery), there were no significant differences between the two groups in any of the measured variables.
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In the other studies [20, 21] the baseline values before administration of NTG were determined.
The TTR of a baseline measurement (before administration of the stable isotope tracer) was subtracted from each sample TTR to account for natural abundance.
Tracer-to-tracee ratios (TTRs) of a baseline measurement (before administration of the stable isotope tracer) were subtracted from each sample TTR to account for natural abundance.
Twenty milliliters of blood were collected into tubes containing EDTA (Greiner Bio-one Vacuette) before starting chemotherapy (baseline) and before administration of each subsequent course of chemotherapy (day 1) until discontinuation of systemic therapy.
Ratings were requested at baseline (immediately before administration of the first dose of study medication); after operation (once the participants were sufficiently awake to respond); and 1 2 hourly thereafter, while awake, for 48 h.
A separate baseline was taken before administration of each drug.
A detailed description of the evaluable immunogenicity population at baseline (visit 1) before administration of the first PCV13 dose (N = 216) is shown in Table 1.
Vital signs, haematologic parameters, blood chemistry, liver panels, and physical examinations were performed at baseline (within 14 days before administration of first drug dose) and throughout the study including treatment termination.
When MAD was divided into baseline MAD (the hour before administration of insulin) and postprandial MAD (the first 4 h after the meal), there was a trend toward increased MAD postprandially from 18.6 ± 1.6% in the baseline period to 22.8 ± 1.1% in the postprandial period (P = 0.088).
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