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Table 1 shows baseline Axis-I and -II diagnoses for the 107 patients included in longitudinal analyses.
To assess whether baseline HPA axis function predicts clinical response.
Both baseline HPA axis function and change in function with treatment will be assessed to see if they predict clinical response to metyrapone defined by the change in MADRS between week 0 and week +5, in an exploratory analysis.
In contrast to relatively spared baseline HPA axis activity, etomidate-induced inhibition of 11β-hydroxylase, which was greater in nonsepsis than in sepsis, was associated with a inhibition of the cortisol response to supraphysiologic doses of exogenous ACTH, regardless of underlying condition and cortisol-binding molecules that hardly affect ACTH-induced cortisol increases [ 11].
The proportion of observations that fall below each possible change from baseline (y-axis) can be read on the x-axis.
The observation that etomidate barely affected baseline HPA-axis activity, independent of the time between admission and etomidate administration and conversely on blood sampling, is supported by the lack of increase in endogenous ACTH with the decrease in the cortisol/11β-deoxycortisol ratio.
Furthermore, exposure to stressors during juvenility affected the HPA axis baseline activity.
Exposure to stressors during juvenility affected the HPA axis baseline activity as was indicated by elevated basal CORT levels.
A lymph node is considered metastatic if at baseline the short axis is ≥10 mm.
In general, at the baseline the HPA axis parameters do not differ in individuals susceptible and resistant to inflammatory disease.
ECG abnormalities at baseline included left axis deviation, signs of LV hypertrophy, conduction delay (QRS >110 ms), and microvoltage in standard leads.
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