During parabolic flight experiments, cells were activated at the onset of μg (or during 1 g for in-flight control experiments) by addition of PMA or CD3/CD28 (or of cell culture medium for baseline experiments) and fixed 20s after the period of altered gravity.
Instead we used the observed baseline when available, and fixed it to the median value of 1.2 for children with missing baseline values.
A constant baseline hazard was assumed and fixed at λ=0.008; this corresponds to the hazard of failure when the longitudinal value is equal to the mean of the process over the 10-year follow-up.
Furthermore, we restrict our attention to the simplest case of a point-exposure RCT (i.e., an RCT in which exposure is applied and fixed at baseline).
Evolution of (A) maturation parameters for males (left) and females (right) in baseline simulations with inherited maturation and fixed growth parameters (X1− X12 = 0.5) and including density-independent growth.
Further comparison of Models A fixed treatment and fixed proportional trial effects) and B (fixed treatment and baseline stratified by trial) are made using Cox proportional hazards models, under a classical approach.
The primary end point was assessed using an ANCOVA model, with treatment, region, and eGFR at baseline as fixed effects and baseline HbA1c as a linear covariate.
With this method, the exposure measured with error (the observed measurement) was replaced with a predicted value calculated from a regression model, again with age at baseline, birth year, fasting time, smoking status and time from baseline as fixed effects and cohort as random effect.
For the Roland Morris Disability Questionnaire the difference between treatment arms was -2.27 (-4.47 to -0.08).> -wrap-foot> *Mean difference = (decision support package – usual care) after adjusting for years of experience and pain severity at baseline as fixed effects and physiotherapist as random effects; negative difference = favours usual care.
We assessed the effect of CAPs exposure on myocardial blood flow using multilevel linear mixed models (Fitzmaurice et al. 2004) containing exposure type (CAPs, filtered air, initial baseline, final baseline) as fixed effects and tissue piece and dog as random effects.
An ANOVA model, containing sequence, period, sex, and baseline value as fixed effects and animal as a random effect, was fitted to all dependent variables.
