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However, most attempts fail because they are not based upon understanding of system complexity, they assume "win-win" situations, they fail to plan for the impacts of society-wide changes happening beyond the project landscapes, and they use top-down – planning – approaches.
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Study of social action through interpretive means (Verstehen) must be based upon understanding the subjective meaning and purpose that individuals attach to their actions.
Further development and testing of therapies based upon improved understanding of the complex pathophysiology of this common and disabling complication is urgently required.
The concept of paradigms can support the case-specific analysis of concrete solution strategies based upon an understanding of the epistemological dimension of sustainability issues.
The fundamental understanding of biology is, in large part, based upon the understanding of genes and their encoded protein products.
Based upon this understanding of protein structure, the initial idea of a protein molecular clock was that the number of amino acid differences found when sequencing the same protein for two different species could be used to measure the time that has elapsed since their divergence from a common ancestor.
Based upon his understanding of the hindfoot anatomy from dissections of stillborn babies, in 1948 he devised a way to correct the feet nonoperatively [ 18].
Indeed, we recently engineered an ACP domain that was predicted to enhance the affinity of these two domains, based upon our understanding of ketosynthase ACP recognition principles.
Based upon our understanding of the lipid signaling events that are triggered downstream of P2X7 receptor activation, a change in the levels of cholesterol may contribute to the sensitization of receptor currents and the dilation of the pore that occurs following prolonged, high-level stimulation.
This has resulted in an unwillingness among public health decision makers to implement relatively simple approaches, based upon an understanding of developmental plasticity and intergenerational influences, to reducing the burden of disease particularly in low socioeconomic groups.
Considerations for adhesion prevention should be based upon an understanding of peritoneal repair, and what goes awry when adhesions develop, as briefly summarized below [1, 2, 3].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com