Sentence examples for based upon the structures from inspiring English sources
A series of m-carborane derivatives was prepared based upon the structures of antiestrogenic drugs and their activities were evaluated by estrogen receptor alpha (ERα) binding assay and transactivation assay using human breast cancer cell line, MCF-7 cells.
Sections of the sequence that show strong similarity may be used to construct a 3D model based upon the structures of the templates.
Based upon the structures of the anti-hapten antibodies described above, we identified a position for introduction of a cysteine mutation, which shall enable hapten-positioned covalent coupling of thiol-containing hapten payloads.
This scoring matrix is derived by a similar procedure as the BLOSUM matrices (Henikoff and Henikoff, 1992 , 1993 are done, based upon the structure alignments of structurally similar protein pairs.
As the first step to design even more effective drugs based upon the structure of fisetin, the present study investigated the structural requirements for the anti-amyloidogenic activity of fisetin by comparing the effects of several structurally related flavonoids on Aβ fibril formation in vitro.
"Based upon the structure of this group, their associations and connected events, there is a reasonable suspicion that these persons pose a threat to national security," the document said.
Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized.
A novel series of cyanoguanidine-piperazine P2X7 antagonists was designed based upon the structure of A-740003.
The ability of Zn II) to inhibit Cu II -induced β2m tetramer formation is Cu II -inducedh this binding mode based upon the structure of the Cu(II)-induced β2m tetramer.
Based upon the structure of the hapten binding antibodies (Fig. 3), we designed and synthesized hapten-linker-thiol-payload modules that fulfilled all the above-mentioned criteria (synthesis details in Supplemental Data).
We then validated the system using six additional pesticides of which tow were predicted to be P-gp inhibitors and four were predicted to be noninteractors, based upon the structure-activity analyses.
