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The ∼10% change identified in our MeDIP experiment is likely to be an underestimate in this region as BATMAN calculations are based upon the reference genome.
A diagram of the gene, based upon the reference sequence, is shown in Figure 1.
And certainly whole chromosome increases in signal relative to the reference strain cannot be accounted for by sequence divergence, since the target probes are based upon the reference strain sequence and diverged sequences are unlikely to out-compete the homologous sequences.
The nutritive requirements were based upon the Dietary Reference Intakes (DRI) [ 24].
Nutritional requirements were based upon the Dietary Reference Intakes (DRI 2002) [ 25], which reflect the current state of scientific knowledge.
Pharmacy will be un-blinded and dispense trial medication based upon the numeric reference prescription, using unmarked bottles, with generic administration details.
For children, height and weight will be used to calculate BMI (kg/m) and age- and sex-adjusted standardized scores (z-scores) based upon the UK reference data [ 31] and LMS methods [ 32] will be used.
They should be identified, in publications based upon the James Franck Papers, with reference to the original manuscripts in the Library of Churchill College.
In the pilot study, variants in mtDNA obtained from peripheral lymphocytes were characterized using an oligonucleotide sequencing microarray with probes based upon the Revised Cambridge Reference Sequence (rCRS [NC_012920]): the Human Mitochondrial Resequencing Array 2.0 (Affymetrix, Santa Clara, CA) [18].
These analyses were conducted on a Roche Hitachi 917 analyzer (Basal, Switzerland) and based upon the International Federation of Clinical Chemistry and Laboratory Medicine IFCCC) standard reference model.
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