Sentence examples for based upon the crystal from inspiring English sources
Alternatively, it was hypothesized that ChEs could be converted into OP hydrolases by using rational site-directed mutagenesis based upon the crystal structure of ChEs.
Based upon the crystal structure of HLA-DQ2, we rationally designed an aldehyde-functionalized, gluten peptide analogue as a tight-binding HLA-DQ2 ligand.
The asymmetric model of the EGFR kinase domain dimer was based upon the crystal structure solved by Zhang and colleagues [ 45].
All other Dpo4 mutants listed in Table 2 exhibited similar trends consistent with the distance variation based upon the crystal structure analysis of apo and binary complexes (data not shown).
DOI: http://dx.doi.org/10.7554/eLife.03720.004 We decided to use an unbiased approach and designed our subsequent Nrp1 variants based upon the crystal structure of the full NRP1 b1 domain.
Rational design of novel inhibitors exhibiting effectiveness against imatinib-resistant mutants of BCR-ABL was carried out by researchers at Novartis Pharmaceuticals, based upon the crystal structure of the imatinib-Abl complex (Schindler et al, 2000; Nagar et al, 2002; Manley et al, 2004).
The structure was assigned based upon the single crystal diffraction and DFT studies.
The models of eEF1A1 and eEF1A2 were created based upon the yeast crystal structure of eEF1A and evaluated for stereochemistry, packing quality and expected accuracy.
In addition, we have generated molecular models of hP2X4 and DdP2XA based upon the zfP2X4.1 crystal structure, and probed their accuracy using N-glycosylation mutagenesis.
The expected distribution that is based upon the syntaxin/munc18 crystal structure (blue trace) closely matches the experimental distribution, where the slight overestimate in distance is within the uncertainty of the prediction.
Additionally, all 6 sites were surface-exposed in the molecular model of hP2X4 based upon the zfP2X4.1 crystal structure (Fig. 6C), suggesting that the model is a good representation of the structure of hP2X4.
