Sentence examples for based upon substrates from inspiring English sources
A dendrogram classification of kinases based upon substrates would be of tremendous use for inhibitor design, cell biology and evolutionary studies.
Peptidomimetic methyleneamino reduced-peptide inhibitors, which have inhibition constants in the picomolar range, were prepared for each plasmepsin 4 ortholog based upon substrate preferences.
The data show that high -Mr TRs can be divided into two groups based upon substrate utilization patterns: a TR1 group and a TR3-like group.
Heterogeneity issues remain to be resolved for biofilm studies; however, models predicted that the D. vulgaris biofilms in the described study were not limited for lactate or sulfate at the given biofilm depths 10-300 μm, Additional file 1) based upon substrate diffusivity with a biofilm accumulation model [ 26].
PI3Ks are classified into four distinct sub-families – commonly referred to as classes I, II, III and IV – based upon their substrate specificities, primary sequences, modes of regulation, and domain structures.
Additionally, we propose a functional model for the transport of metal ions by SsTroBCD based upon similar substrate transporters.
High- Mr TRs can be classified into two groups based upon different substrate utilization patterns.
Below we discuss our evidence for dividing the TRs listed in Table 1 into two groups based upon the substrate utilization pathways shown in Figure 1.
Strikingly, clustering slc genes based upon known substrate specificity and comparing their expression domains to those observed in vertebrate nephrons revealed a remarkable degree of similarity in the overall structural/functional organization of the planarian and rodent systems.
Findings from five enzyme variants and four model substrates have enabled a model to be proposed involving catalysis based upon acyl-CoA substrate loading followed by differential rates of hydrolysis.
A new nomenclature for CYP74 enzymes, based upon the confirmed substrate and product specificities of recombinant proteins, has recently been proposed [ 8] and which assigns CYP74C to only HPLs with dual specificity.
