We are developing new approaches based upon Structures for Lossless Ion Manipulation (SLIM) that aim at enabling much more complex sequences of ion manipulations in one platform, with potential advantages that include greater speed and reduced sample size requirements.
Our interest in the relative thermodynamic energetics of competing secondary structures has led us to examine the relative energies and enthalpies of various secondary structures and the relative effects of single-amino acid mutations in models of these secondary structures based upon peptide structures made from all Ala residues.
This scoring matrix is derived by a similar procedure as the BLOSUM matrices (Henikoff and Henikoff, 1992 , 1993 are done, based upon the structure alignments of structurally similar protein pairs.
A comparison of these two structures and the utilisation of hybrid methods based upon ternary structure prediction and flexible fitting provide key insights into the structure of the OL in its native state, into the position and structure of the N-terminal domains of TraO/VirB9 and TraF/VirB10 in the IL and their links with the OL.
Based upon this structure, a model was proposed for the structure of an octameric repressor that forms both in the presence and absence of DNA.
A critically important outcome of the structure-based sequence phylogenetic reconstitution is the determination that, consistent with our analysis based upon TFP structures alone, Prod1 is not the ortholog of CD59.
The CMA structural method scoring system assigns weighted numerical scores based upon hierarchical structure, cross-links, and concept-links [ 9, 21].
"Based upon the structure of this group, their associations and connected events, there is a reasonable suspicion that these persons pose a threat to national security," the document said.
Statistical results from membership in research alliances vary based upon organizational structure.
Two new agents based upon the structure of the clinically active prodrug laromustine were synthesized.
