One SNP marker was selected for further testing based upon its specificity for the Doubs strains (Table 1).
Based upon their specificity for the Bacteroidetes and Chlorobi species, these molecular markers provide novel and more definitive means for identifying and circumscribing species from these groups.
For all further experiments, we selected a panel of monoclonal antibodies (TA, TB, UA, UB, RC, RD, DA, and DB) based upon their specificity and sensitivity.
There are at least four general subcategories of PI3K pathway inhibitors, based upon target specificity, that are currently in clinical use or in various phases of clinical testing.
The autolysis-resistant tobacco etch virus protease S219 V mutant (hereafter, TEV) and its wild type cleavage sequence (ENLYFQ/G) were selected as trans-cleavage partners based upon the specificity of this system and its extensive use in mammalian cells.
The resulting protein can deliver neurotoxin endopeptidase to a cell based upon its receptor specificity, inhibiting secretion from the selected cell.
We considered consistently the two traditional clinical outcomes laboratory confirmed cases (LCC) and clinically confirmed cases (CCC) —that have been sometimes also defined as "efficacy" and "effectiveness," respectively, based upon their different specificity (much lower for CCC).
Strikingly, clustering slc genes based upon known substrate specificity and comparing their expression domains to those observed in vertebrate nephrons revealed a remarkable degree of similarity in the overall structural/functional organization of the planarian and rodent systems.
PI3Ks are classified into four distinct sub-families – commonly referred to as classes I, II, III and IV – based upon their substrate specificities, primary sequences, modes of regulation, and domain structures.
It remains to be established whether the subclassification based upon ACPA fine-specificity profiles is clinically meaningful.
