The sample size of 22 patients was determined on an empirical basis, based upon prior experience with small sample sizes in phase I studies [ 22, 23].
We submit that this process conforms to the prose definition of pretest probability from a clinician's perspective: "the probability of the disease of concern in one patient, based upon prior experience with many patients who had similar clinical characteristics as the patient under consideration" [ 3, 4].
The flight team staff includes both paramedics and nurses who are chosen based upon prior relevant critical care experience.
The development of the Virtual Patient will change conventional medicine, which has been based upon experience and expectation, into "predictive medicine" that will have the capacity to develop solutions based upon prior understanding of the dynamic mechanisms and the quantitative logic of human physiology.
The dose was selected based upon prior studies [ 6, 14].
Empowerment was measured using several conceptualizations based upon prior literature [ 8, 9] and data availability.
The strategy was based upon prior knowledge of the regulation of equisetin production.
"My mandate from the company is to consider the options for dealing with issues surrounding the ignition switch matter, and to do so in an independent, balanced and objective manner based upon my prior experience," Feinberg said.
Instead, the number of dogs enrolled was based upon the prior experience from previous studies of plasma biomarkers from the same clinic [ 25, 32, 33].
