Sentence examples for based upon our X-ray from inspiring English sources

These inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor 1 bound to SARS-CoV 3CLpro.

A series of novel oxyindole-derived HIV-1 protease inhibitors were designed and synthesized based upon our X-ray crystal structure of inhibitor 2 (TMC-114) bound to HIV-1 protease.

Based on our X-ray data, we propose a unique catalytic feature for the immunoproteasome subunit β5i/LMP7.

A prototype pipework scanning system based upon energy dispersive X-ray diffraction (EDXRD) has been produced, for which system development and preliminary results are presented here.

MSCT plaque assessment is based upon the variable X-ray attenuation of the tissue components.

A series of novel macrocyclic amide-urethanes was designed and synthesized based upon the X-ray crystal structure of our lead inhibitor (1, OM99-2 with eight residues) bound to memapsin 2. Ring size and substituent effects have been investigated.

A model of 4f was created based upon the X-ray structure of 3a-bound β-secretase.

A model of 4c was created based upon the X-ray structure of 2-bound β-secretase which revealed critical interactions in the active site.

To provide a real-space picture of the dynamic properties of PaDDAH, we performed atomistic, explicit solvent MD simulations of apo and l-citrulline-bound PaDDAH, based upon the X-ray coordinates of the protein/ligand complex.

Models of the C-terminal domain (amino acid residues 110 228) of the ALRQ, AFRQ, and ALHQ variants of ovine PrP were built using the program MODELLER [ 31] using default parameters based upon the X-ray structure of ovine PrP (PDB code 1TPX) [ 32].

Based upon the activity and X-ray crystallographic studies of tri-substituted benzene derivatives containing carboxylic acid, acetamido and guanidine groups, we investigated the effect of the fourth substituent to fulfill the fourth pocket of neuraminidase enzyme.