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Nitrosylcobalamin (NO-Cbl) is a chemotherapeutic pro-drug derived from vitamin B12 that preferentially delivers nitric oxide (NO) to tumor cells, based upon increased receptor expression.
Folic acid conjugation of the hairpin resulted in significantly increased cellular uptake relative to the nonconjugated hairpin based upon increased Dox fluorescence into 4T1 breast cancer cells.
It has been proposed that individuals gain control over their tics through the development of compensatory mechanisms that lead to enhanced control over motor outputs based upon increased tonic inhibition [ 8, 10, 11, 18 20].
Here we offer a novel perspective on how this increased control over motor outputs can arise as a consequence of localized increases in tonic inhibition based upon increased levels of nonsynaptic, extracellular GABA concentration that operate to alter the gain of cortical spinal excitability (CSE) locally.
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This is the culmination of an inverted justice system which has come to characterize the United States, a justice system based upon increasing the power and wealth of the corporate-state.
The role of subfunctionalization as a transition is based upon increasing the mutational space accessible to duplicates to neofunctionalize with removal of selective constraint at a binding site.
The slides were classified according to the most severe abnormality detected using one of five categories based upon increasing nuclear abnormality.
For these same reasons, life science research is evolving into international multi-disciplinary collaborations based upon increasing data sharing among labs and institutions.
Our experimental design utilizes the mean objective cost of uncertainty (MOCU), which is an objective-based uncertainty quantification scheme that measures uncertainty based upon the increased operational cost it induces.
Based upon the increased myofilament calcium sensitivity, impaired diastolic function may ensue.
This characterization is based upon significantly increased risk of leukemia in highly exposed workers and is supported by evidence from animal studies.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com