Sentence examples for based upon expression of from inspiring English sources
A recently developed novel and efficient screening assay based upon expression of a dicistronic mRNA (RHO IRES SEAP) containing both RHO and reporter (SEAP) cDNAs was used to compare the hhRz 266 lead candidate to another agent (Rz525/hhRz485) already known to partially rescue retinal degeneration in a rodent model.
To understand this finding, we established a model system based upon expression of GFP-lamin A in CRC cells.
For phenotyping of rectal and peripheral CD8+ T-cells, unstimulated cells underwent the same gating strategy except that the CD3+CD8+ population was further divided based upon expression of phenotypic markers rather than response markers.
CTCs are partially purified by immunomagnetic separation based upon expression of either EpCAM.
Some studies have also used a new CellSearch System technology that employs immunomagnetic separation of epithelial cells based upon expression of cytokeratins or EpCAM and visualization of the tumor cells by immunoflorescent microscopy [ 30].
As in the chicken CSF1-Fc-treated embryos described above, whole mounts of tissues of the chicken CSF1-Fc-treated birds could be distinguished from control based upon expression of the CSF1R-mApple reporter gene.
Selection for many of these putative CSCs is based upon expression levels of either the ABC superfamily of membrane transporters [ 2] or the aldehyde dehydrogenase (ALDH) gene superfamily encoding detoxifying enzymes for many pharmaceuticals and environmental pollutants.
In the present context, we have also adapted this approach to estimate an inflammation profile for human psoriasis, based upon expression patterns of human genes orthologous to signature transcripts associated with individual mouse leukocyte populations (Figure 9).
Principle component analysis revealed that Pecam1-positive (n = 25), Pdgfrα-positive (n = 23), and Cdcp1-positive (n = 15) cells formed three distinct clusters and each cell type could be unambiguously identified based upon expression levels of known EPI, PE, and TE genes.
In order to identify potential molecular targets for TNBC related to loss of the critical tumor suppressor functions of p53 and pRb, we hypothesized that identification of a gene expression signature based upon the expression of an oncoprotein whose mechanism of transformation results in the inhibition of p53 and Rb function would be highly relevant to human TNBC.
Notably, in a recent study, gene expression patterns were shown to be predictive of major cytogenetic patterns seen in meningiomas (chromosome 22 or 22q loss, loss of 1p36 alone, complex karyotypes with loss of 1p36 and/or 14q and diploid) based upon altered expression of a combination of genes within the regions of altered dosage and genes outside these regions [ 42].
