The diagnosis of incident dementia (as well as that of pre-fracture dementia) will be based upon consensus in an expert panel consisting of one experienced old age psychiatrist (KE) and one experienced geriatrician (TBW), who will have access to all clinical information and results of the cognitive tests, but are blinded to allocation.
Hence, recommendations in the guideline were based upon consensus and secondary care-based trials [ 2].
The diseases were then categorized as common or rare based upon the consensus of the investigators.
Progress into Phase II will be based upon the consensus judgment of the Quartet of whether conditions are appropriate to proceed, taking into account performance of both parties.
Topology of the phylogenetic trees were generated from a Bayesian analysis with MrBayes (version 3.1 parallel, on an eight processor linux system) [ 46], using the Gamma rate parameter and the WAG model, and is based upon the consensus tree of two converged runs of 3,000,000 generations using 4 chains, burnin of 500,000 generations; branch support represent posterior probabilities.
Sample size estimation was based upon the consensus opinion of the surgical members of the design team, which suggested that a change in 5-year survival from 20% (D1) to 34% (D2) could be realistic and medically important.
The definitions of possible, probable, and definite breakthrough fungal infections were based upon clinical consensus guidelines on opportunistic fungal infections in cancer patients and stem cell recipients [ 6].
This paper identifies some of the problems in using and interpreting the results for predicting ageing based upon ISOS consensus standard test data.
