Sentence examples for based upon alterations from inspiring English sources

Heritable changes in gene expression that are not based upon alterations in the DNA sequence are defined as epigenetics.

Most reports focus on classifying samples as safe or contaminated based upon alterations in the spectra determined by multivariate analysis; however, better estimations of mycotoxin concentrations appear promising.

The proposed alternative entrance modifications were based upon structural alterations of the inlet system (such as a jetty extension or submerged weir) and non-structural scenarios (such as a change of the time of the dredging campaign or the deposition location of the dredged material).

Unsupervised hierarchical clustering analysis based upon genetic alterations on all chromosomes was performed.

Unsupervised hierarchical clustering analysis based upon genetic alterations on all chromosomes showed that all pre- and D21 post-biopsies clustered together (N=17 cases).

The possible maintenance of the genes for the biosynthesis of these polysaccharides, and their occurrence in halophytes from different evolutionary periods, prompts an interesting insight in regard to atavisms: "An organism's past not only constrains its future; it also provides as legacy an enormous reservoir of potential for rapid morphological change based upon small genetic alterations" [20].

Based upon the noted alterations in phosphoprotein activation levels, as discussed above, we examined the TargetScan miRNA prediction database [ 30] for potential kinases that might be direct targets of miR-34a that could account for these alterations.

38 However, this equation requires extensive evaluation using technologies not easily accessed clinically, and it is not helpful therapeutically, since therapies are based upon the specific alterations rather than lipodystrophy per se.

Further experiments with impermeable dextran polymers indicated an average internal diameter of ∼2.4 nm, a conclusion we arrived at based upon the polymer-induced alteration of the access resistance contribution to the nanopore's total resistance.

Array Comparative Genomic Hybridization (array CGH) is a powerful whole genome profiling technology capable of detecting both DNA copy gain and loss that has the potential for unbiased classification of tumor specimens based upon the constellation of genomic alterations that they possess.

Based upon this analysis it is predicted that alterations in the expression of Oct4 correlated genes such as Ccnf or Nipp1 that impact the functional status of pRb (or pRb family member p107) would have profound consequences.