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An interview guide was based upon a structured literature review [ 10].
Demographic and clinical data at the baseline were obtained from medical records and face-to-face interviews based upon a structured questionnaire.
Clinical diagnosis in each patient was based upon a structured review of the clinical history and examination findings as recorded in the case file.
Initially developed by our study team and then refined based upon a structured literature review, the organizing framework explicitly describes and categorizes important caregiving activities and outcomes of both caregivers and care recipients.
All subjects were diagnosed by a physician as having moderate to severe MDD using DSM IV criteria based upon a structured clinical interview, with severity as defined by a Hamilton Depression Rating Scale (HAMD-17) [ 11] greater than or equal to a score of 17. Study subjects were treated five days per week for four weeks, with treatment consisting of a single 30-minute session.
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The method is based upon a secondary structure prediction algorithm for folding sequence alignments [ 17] combined with an algorithm (called RNAz) [ 9] that has been trained to discriminate between sequence alignments of ncRNA sequences and their randomized counterparts [ 9].
The compounds, based upon a phenoxypropanolamine core structure with various meta-, ortho-, para- and amine-substituents, displayed binding affinities (pKi) for the human β1-AR ranging from 5.49 to 9.35.
Great care must be taken by the authors when postulating biophysical characteristics of rice Hbs using only homology models based upon a single crystal structure.
The activation of caspases is a major player and decoder in the process of controlling apoptosis via the regulation of redox equilibrium and disequilibrium, and the fragility of the Bcl-2 major breakpoint region to be cleaved is based upon a non-B-DNA structure [6 9].
It is based upon a strategy that identifiable structures or submodels can be generated by systematically eliminating parameters of the original model until it becomes identifiable [ 19].
Based upon a model for the structure of the pre-translocation state in which the terminal base pair of the duplex occupies the same configuration as the nascent base pair does in the post-translocation state ternary complex, we therefore hypothesized that an analogous destabilization of the pre-translocation state would be caused by the presence of a 2′-OH group at the primer terminus.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com