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Internet-based trials may be a cost-effective approach for assessing low-risk interventions.
The significantly low rate of grade 3 4 toxicities in this study when compared to other irinotecan-based trials may be explained by the ethnic difference or the continuous infusion of 5-FU or the dose intensity of irinotecan.
Even if DTC evidence was available, ITC evidence based on other trials may be useful because of differences in patient characteristics and study characteristics such as length of follow-up [ 11].
Failures in trials may be based on lack of efficacy, excessive side effects, or challenges in trial execution.
The reason for not basing studies on single clinical trials may be related to the chronology of ACEIs being available on the market, i.e. the 1980s, before the ARBs.
Based on the scientific hypothesis behind the trial, comparative trials may be classified as superiority, equivalence, or noninferiority trials [ 104, 105].
Based on the risk levels of toxicity for each patient, future clinical trials may be designed to maximize individual therapeutic gain.
Phase 1 trials may be under-represented in the data base since some foreign phase 1 trials are not conducted under an investigational new drug application [ 7].
Trials may be carried out publicly & more are expected.
However, such trials may be ethically questionable.
The lack of patient centeredness in clinical trials may be partially addressed through trial design.
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