There is a lack of evidence from well-designed population-based trial to evaluate the population benefits from implementing these high-risk strategies, particularly in resource-poor settings.
Setting up and carrying out a randomised controlled trial to evaluate a community based public health or health promotion intervention, whilst not impossible, is acknowledged internationally as likely to be expensive and potentially inappropriate [ 4, 14].
However, the most important trial on neoadjuvant chemotherapy is certainly the EORTC55971 trial (ClinicalTrials.gov identifier: NCT 00003636), which constitutes the first prospective multicentric trial to evaluate preoperative platinum-based chemotherapy followed by IDS versus primary surgery followed by postoperative chemotherapy.
Our study is the first randomized controlled trial to evaluate fully automated closed-loop glucose control based on subcutaneous continuous glucose monitoring in critically ill patients.
Based on encouraging results from animal studies, we performed a clinical trial to evaluate the anti-obesity effects of Yerba Mate on humans.
We devised a randomised controlled trial to evaluate the effectiveness and efficiency of an intervention based on case management care for frequent emergency department users.
Did doctors recommend entering a clinical trial to evaluate newer therapies?
The Big Lung Trial [5,6] was a pragmatic, UK-based toial to evaluate the impact of cisplatin-containing chemotherapy in NSCLC in all settings: early, locally advanced and metastatic.
Another study used a decision analytic model based on published clinical trials to evaluate the cost-effectiveness of linezolid, daptomycin, and vancomycin in treating MRSA SSTIs.
We conducted a meta-analysis based on randomized controlled trials to evaluate the effect of omega-3 fatty acids on the risk of cancer incidence, nonvascular death, and total mortality.
Therefore, we performed a systematic review and meta-analysis based on relevant published controlled clinical trials to evaluate whether PDT offers any advantages over anti-VEGF in terms of anatomic and functional outcomes when treating PCV.
