Here we present the design of a large, community-based trial evaluating the effects of switching from immediate-release carbamazepine to twice-daily, beaded, extended-release carbamazepine (Carbatrol).
The ongoing Treat CTC trial is the first international, liquid biopsy-based trial evaluating the concept of targeting chemoresistant minimal residual disease: detection of CTCs following adjuvant chemotherapy (adjuvant cohort) or neoadjuvant chemotherapy in patients who did not achieve pathological complete response (neoadjuvant cohort).
Examples of the international context at that time are that in the Australian penal system, a prison based randomised controlled trial evaluating the effectiveness of methadone maintenance had just been published [ 7].
The results of this primary and secondary care based randomised placebo controlled trial, evaluating the efficacy of individual and group hypnotherapy treatment in IBS, will contribute to the scientific basis of IBS management.
The 0.50 mg PALO dose was chosen based on an efficacy trial evaluating the noninferiority of three oral PALO doses, 0.25, 0.50 and 0.75 mg, compared with i.v. PALO 0.25 mg [ 7].
Based on an earlier controlled clinical trial evaluating the effect of an IDM program in mild to moderate COPD, we found the greatest improvements on quality of life in patients with an MRC dyspnea score >2 [ 25].
The earliest trial evaluating the efficacy of a hospital based geriatric evaluation unit was conducted in 1979 at the Sepulveda VA Medical Center.
Four years later, a USA randomised controlled trial evaluating the effectiveness of prison based opiate maintenance therapy was published.
This paper presents the results of the first trial evaluating the effectiveness of a community based intervention for persons with dementia and their caregivers.
And it was based on well-controlled clinical trials evaluating the use of this compound in the treatment of a specific condition".
The current randomized clinical trial evaluated the efficacy of an adjunctive behavioral smoking cessation treatment based on learning theory.
