In particular, the Asp residue of Motif II may participate in both zinc ion coordination and act as a general base to generate a hydroxide ion for nucleophilic attack on the scissile phosphodiester bond at the cleavage site [ 25, 29].
The prospect of deprotonating this most powerful of bases to generate a TMP-based dianion would seem a challenge too far.
They use probabilistic or rules-based inference to compare patient information with a knowledge base to generate a differential diagnosis list that is typically ranked in descending order of likelihood.
Their difference relies on the way immigrants are generated, e.g., in random immigrants they are generated randomly whereas in elitism- and memory-based the best solution from previous environments is retrieved as the base to generate immigrants.
Ms. Corwin's position has placated conservatives, who stand to play an important role in the election, as both campaigns rely on their political bases to generate turnout in a special election that may not register with the larger electorate.
Building out a significant user-base to generate momentum is the obvious high hurdle.
Electrochemically generated base (EGB) was cathodically prepared from pyrrolidone, and it was used as an efficient base to generate an anion of methyl phenylacetate.
Our most effective strategy involves preserving the existing glyosidic bond of thymidine and manipulating the base to generate the exocyclic methylene moiety.
However it also notes that games and stickers won't work for social messaging's smaller fish — arguing that this monetisation method demands large user-bases to generate the required revenues.
The low limit on the ownership of resources that qualifies the owner to discharge zakah obligation is meant to keep a broadened base to generate resources for the poor.
Neither did they stoke the Republican base to generate more turnout.
