Commonly utilised ante-mortem diagnostic tests for JD include immunodiagnostic tests for serum antibody by ELISA or organism based tests to detect the presence of the bacterium, such as faecal culture or PCR.
The Lombard test, a non-parametric rank-based test to detect change points in the moments of a time series, has been recently used in the hydrologic literature to detect change points in the mean and variance.
Tumors with loss of MLH1 IHC staining will need to undergo an additional PCR-based test to detect for MLH1 gene promoter methylation [ 15, 71].
The sequence information from the viral transcripts could form the basis of an RT-qPCR-based test to detect the level of viral presence in mycelium.
A gene-expression-based test to detect cancers that does not rely upon the availability of tissues or cells from the diseased area has not yet been described.
With the aim of providing breeders with an accurate DNA-based test to detect long-hair carriers in Poitou crossbred descendants, we performed a mutation screening of FGF5 in various donkey breeds.
Knowing that Leishmania antigens are excreted in the urine of VL patients, we developed a sensitive urine-based test to detect antigens with which to evaluate treatment [ 18, 19].
In August 2011, the FDA approved two drugs with companion diagnostic tests: vemurafenib with a PCR-based test for the V600E activating mutation in the oncoprotein BRAF in metastatic melanoma [ 42], and crizotinib with a fluorescence in situ hybridization (FISH -based test to detect ALK rearrangements in NSCLC [ 7].
We applied a dN/ dS-based test to detect positive selection as it is easy to use on a large scale, it is one of the most stringent tests [ 38- 40], and it has been applied successfully in many similar cases (for examples, see above).
We provide diagnostic plots and a simple logistic regression based test statistic to detect these intensity related defects in the processed data.
