There are few studies that address the cost of oral based testing in the field; however, the slow uptake of oral HIV testing by resource constrained countries may be due to the cost per test, which is higher than most blood based tests [ 14].
However, despite these limitations, the prospective design of the study, the evaluation of 6 in vitro assays for TB diagnosis (5 experimental and 1 commercial) and the relatively large number of HIV-infected individuals enrolled to evaluate the performance of the different immune based tests in clinical practice render the results solid.
The samples produced were subjected to two different nonstandard and relativity based tests in order to examine the durability of the materials used under rain and flood.
However, the prospective and multicenter design of the study, the high consistency of data across the different centers and the large number of patients enrolled to evaluate the diagnostic accuracy of different immune based tests in clinical practice render the results robust.
A final advantage of the use of molecular based testing in a clinical setting is the ability to include other targets e.g. as adenovirus, BVDV and bacterial pathogens.
They use an augmented model to maintain the randomisation balance between groups which corresponds to the Cox model based test statistic in the semi-parametric approach of Robins & Tsiatis.
As independence test we used the Fisher Exact Test for marginal independencies and a simulation based test (implemented in coindep_test in the R-package vcd) for conditional independencies.
Permutation based testing, implemented in the BAMM package was used to assess statistical significance at cluster level, corrected for covariates.
Either online or paper based test was used in the previous years.
A PCR-SSCP based test was developed in order to detect the last mutation, which is responsible for the hypotrichotic phenotype.
In [6], Chessa and Santi present a comparison based testing strategy in which the diagnosis model exploits the one-to-many communication paradigm typical of ad-hoc networks.
